At 01:56 a.m. May 10, 2022 Beijing time, the Long March-7 Y5 launch vehicle carrying Tianzhou-4 cargo spacecraft blasted off at Wenchang Spacecraft Launch Site. After around 10 minutes, Tianzhou-4 successfully separated from the rocket and entered its designated orbit. At 2:23 a.m., the spacecraft's solar panels were successfully deployed and working normally, and the launch was a complete success. Subsequently, Tianzhou-4 cargo spacecraft will rendezvous and dock with the space station assembly.

This launch marks the 22nd launch mission of China Manned Space Program, the first launch mission for China Space Station construction after transformed from the key technology verification stage to the on-orbit construction stage, and the 420th flight of the Long March series launch vehicle.